@ikonha is an MD, and is excited about N-Acetylcysteine (NAC) https://zeroes.ca/@ikonha/114804250543332732 for Long COVID mitigation and more
And - wow, I see why! The mechanisms of action in this paper relate to lots of LC and ME/CFS data!
You know the evidence of mitochondrial dysfunction in LC?
Mitochondrial resilience
Neurogenesis-inducing ability reduces apoptosis of mitochondria
LC persistent infection reservoirs, and re-activation of latent viruses?
Antiviral properties
Immune modulation, anti-NF-KB properties, and other unexplored mechanisms
SARS-CoV-2 is an endothelial disease?
Vascular endothelial growth factor
Inhibition of vascular permeability as seen in human keratinocytes.
Fatigue which in some cases responds to ATP donors like creatine?
Adenosine triphosphate (ATP) and nitric oxide (NO) production
Increased ATP production in some cells like fibroblasts in vitro. Increased nitric oxide production as demonstrated in human studies
Rapid organ or system senescence (aging)?
Some have suggested that cysteine deficiency as we age is responsible for loss of youth and loss of health and quality of life and contributes to sarcopenia
all https://pmc.ncbi.nlm.nih.gov/articles/PMC8211525/ , and
Combined treatment with the α2A-adrenoceptor agonist, guanfacine, and the anti-oxidant, N-acetylcysteine (NAC) reduced the cognitive deficits (“brain fog”) associated with long-COVID19 in eight out of twelve patients.
from https://www.sciencedirect.com/science/article/pii/S2667257X22001000
and I see https://old.reddit.com/r/RVVTF/comments/mhlxbr/nacetylcysteine_to_combat_covid19_placebo_vs_nac/ in my ancient bookmarks
I don't have time to go any deeper down this rabbit hole right now - but hopeful stuff!