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#stress

18 posts13 participants0 posts today
Public *
Snowshadow 🇨🇦

I have a serious problem with low blood pressure and I am wondering if I should tell my doctor I found a way to raise it up to 20 points. (not joking!)

5 minutes on Bsky...works every time to raise my blood pressure to the point I am not passing out when walking.

👉 NOTE: If you have high Bp and you want to keep it lower don't venture off Fediverse.

Edit: I own a Bp monitor.

#Socialmedia#Fediverse#Stress
Public
LisaH

You know, once I get past this moving/garage sale I'm having Sunday (despite swearing I would never ever do this again), I may even relax for a day #mentalhealth #stress #DontWantToTalkToAnyone

Aside from the 4 biggest items (TV, huge framed Aboriginal painting, futon and feather bed) everything is basically packed #sisyphus

However I am not going to pay $65 for 2 boxes and foam corners to pack the painting. I will find some cheaper way to protect it in the shipping pod #MovingIsARipOff

Public
Lisa J. Warner / Lisa Luv

🎶🎵🎼🤗💜💛🌐🌍💛💁🏿*Showing Light!*& Love to others will bring you fulfillment!*& Joy!*Amen!🤗💚💗🧡❤️🕊️💚🌐🌍🧡💁🏼‍♀️*Everything feels better when you pray!*Amen!🤗🌎🌐❤️💁🏿*Prayer Works!*Amen!🤗🌐🌍🧡💁🏼*FRIDAY GOOD AFTERNOON "*RELEASE IN PRAYER ALL YOUR WORRIES!*ANXIETIES!*& STRESSES TO GOD*AMEN!" MUSIC SHARE!🤗🎼🎵🎶👉
#music #Friday #Good #Afternoon #Release #Worries #Anxiety #Stress #Prayer #GOD #Love #Jesus #Christ #Holy #Spirit #Believe #Faith #Hope #Peace #Savior #Light

I'm On The Outside (Looking In) youtube.com/watch?v=JiEGilk2JU

youtube.com- YouTubeEnjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
Public
Lisa J. Warner / Lisa Luv

🎶🎵🎼🤗🙏🏻🌐🌍🧡💁🏼‍♀️*Everything feels better when you pray!*Amen!🤗🙏🏿🌎🌐❤️💁🏿*Prayer Works!*Amen!🤗🙏🛐🧡💜💛💚💗🌎🌐❤️🫂👑✝️🕊️💦💞🌍💞💫❤️‍🔥💚💗🫂💒👍🤓🌐🌍🧡💁🏼*FRIDAY GOOD AFTERNOON "*RELEASE IN PRAYER ALL YOUR WORRIES!*ANXIETIES!*& STRESSES TO GOD*AMEN!" MUSIC SHARE!🤗🙏🏻🙏🏿🙏🛐🧡💜💛💚💗🌎🌐❤️🫂👑✝️🕊️💦💞🌍💞💫❤️‍🔥💒👍🤓🤗🎼🎵🎶👉
#music #Friday #Good #Afternoon #Release #Worries #Anxiety #Stress #Prayer #GOD #Love #Jesus #Christ #Holy #Spirit #Believe #Faith #Hope #Peace #Savior #Light

Tears on My Pillow youtube.com/watch?v=WeAYJBCuuQ

YouTubeTears on My PillowBy Little Anthony - Topic
Continued thread
Public
Nonilex

The changes come a week after a supervisor in the tower was arrested & accused of punching another controller in the face over a minor dispute about work, & they follow efforts by the #FAA to reduce #stress among staff still grappling with January’s catastrophic midair collision of a passenger plane & a military helicopter.

#safety#FederalAgencies#Trump
Public
Nicola Romanò

Our new preprint is now out!

Dynamic transcriptional heterogeneity in pituitary corticotrophs

biorxiv.org/content/10.1101/20

We analysed publicly available single-cell RNA sequencing data of pituitary gland tissue and looked at corticotrophs, cells that are central to mediate stress responses.

We identified several transcriptional states in these cells that are related to how they respond to stress. Cells are able to transition between these states and this might be helpful for them to respond to stress coming at unpredictable times.

We also highlight issues related to using scRNAseq to look at functional subpopulations of cells.

bioRxiv · Dynamic transcriptional heterogeneity in pituitary corticotrophsA large body of evidence has shown that corticotrophs, the anterior pituitary cells central to the generation of hormonal stress responses, exhibit heterogeneous functional behavior, suggesting the presence of functional sub-populations of corticotrophs. We investigated whether this was the case at the transcriptomic level by conducting a comprehensive analysis of scRNA-seq datasets from rodent pituitary cells. We envisaged two alternative scenarios, one where robust subtypes of corticotrophs exist, and the other where these subpopulations were only transient states, possibly transitioning into one another. Our findings suggest that corticotrophs transition between multiple transcriptional states rather than existing as rigidly defined subpopulations. We employed marker gene-based comparisons and whole transcriptome label transfer approaches to analyze transcriptional signatures across datasets. Marker-based clustering revealed strikingly low similarity in the identified subpopulations across datasets. This analysis evidenced the presence of transcriptional states with different functional relevance, related to different stages of hormonal signalling. Similarly, the label transfer approach, which considers non-linear interactions across the entire transcriptome showed that transcriptional states could be detected across independent datasets. This classification relied on broader gene expression patterns rather than conventional marker genes, reinforcing the notion of continuous rather than discrete cell states. Furthermore, trajectory analysis by RNA velocity indicated dynamic transitions between transcriptional states, suggesting the presence of transcriptional mechanisms facilitating rapid recruitment of corticotrophs in response to physiological demands. Our findings align with evidence from other endocrine cell types, such as lactotrophs and pancreatic β-cells, where hormone secretion is linked to fluctuating transcriptional activity. The observed transitions in corticotroph states suggest a mechanism allowing flexible hormonal responses to unpredictable and time-varying stressful events. Additionally, this study highlights the challenges associated with scRNA-seq methodologies, including data sparsity, batch effects, and pseudoreplication, underscoring the need for rigorous experimental design and reproducibility in single-cell transcriptomics research. These insights contribute to a broader understanding of pituitary cell plasticity and endocrine adaptation mechanisms. ### Competing Interest Statement The authors have declared no competing interest.
#scrnaseq#stress#physiology
Public
StauBot

Viele 🚗 🚚 🚗 treffen sich gerade auf der A13: Dresden -> Schönefelder Kreuz, zwischen 0.9 km hinter AS Großräschen und 8.4 km vor AS Bronkow und blockieren die #Autobahn.

Möglicherweise freuen sie sich darüber, dass künftig viele #Kommunen nach der Novelle des #Straßenverkehrsgesetz​es Tempo 30 Zonen ausweiten könnten. Endlich weniger #Stress für #Autos. #Verkehrsberuhigung - sooo schöööön. (Quelle: Agora #Verkehrswende)
agora-verkehrswende.de/fileadm

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